3D Cell Culture Market Size and Share to Surpass USD 8.9 Billion by 2035 | Roots Analysis

According to a recently published report by Roots Analysis, the increasing research activities to develop novel therapeutics have led to a surge in the demand for advanced technologies such as 3D cell culture for drug research and development. 

LONDON, Jan. 16, 2024 /PRNewswire/ -- 

Global 3D Cell Culture Market Overview

The global 3D cell culture market is growing exponentially; it is estimated to be worth USD 1.5 billion in 2023 and is anticipated to reach USD 8.9 billion by 2035. It is expected to grow at a compounded annual growth rate (CAGR) of 16.7% during the forecast period from 2023 to 2035. 

3D cell culture is an artificial culture environment that enables cells to grow in an extracellular framework in three dimensions. In recent years, 3D cell models have increasingly been used in drug development processes to understand the mechanism of diseases and the therapeutic efficacy of drugs. Earlier drug testing in biomedical research has been done using animal models such as mice as they have 80% similarity with human genetics, anatomy, and physiology. However, animal models may generate accurate results because sometimes drugs may or may not be expressed in the systems, leading to false predictions. Drug research using animal models also poses an ethical concern and requires skilled labor to handle animal breeding / housing. Considering the aforementioned concerns, pharmaceutical companies shifted to 3D cell culture (an advanced in-vitro drug testing model miming human cell culture). 3D cell culture systems help drive research across various applications, including cancer research, diagnosing, drug discovery, and tissue engineering.  The system involves cell-to-cell interaction, enabling accurate evaluation of cellular response and drug toxicity. Owing to its significance, 3D cell culture systems have been adopted across various drug research activities, which is anticipated to drive the market during the forecast period.

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3D Cell Culture Market Report Scope:

Market Drivers

The 3D cell culture market is driven by several factors, including increasing focus on the development of alternatives to animal models for drug testing.  The increasing adoption of large-scale 3D cell culture models in drug development and screening processes has further fueled the market. These models help evaluate human tissue complexity, enabling accurate drug efficacy, safety profiles, and toxicity assessment. The rising incidence of chronic diseases across the globe has also surged the demand for proficient and reliable cell culture models, which is anticipated to become a significant growth driver of the 3D cell culture market.

Market Restraints

3D cell culture has been adopted worldwide to study the therapeutic efficacy during drug development. However, some market restraints still limit the growth of the 3D cell culture field. One potential reason is the high cost of implementing the 3D cell culture technology. Also, the maintenance of 3D cell culture equipment is complex and requires specialized training or skilled personnel, which enhances the overall cost of installing 3D cell culture. The lack of standardized protocols for implementing 3D cell culture poses several challenges in terms of comparability of results across drug development studies.

Growth Factors

Despite the market restraints, the 3D cell culture market is growing exponentially due to the increasing trend of personalized medicine and ongoing technological advancements to enhance the reproducibility of 3D cell culture-based experiments. Increasing funding from several industrial and non-industrial players to boost the production of 3D cell culture techniques has further fueled the market during the forecast period. Moreover, increasing support from regulatory authorities such as the FDA encourages the adoption of 3D cell culture techniques in pharmaceutical industries, which is estimated to be a major growth factor driving the market during the forecast period.

Recent Developments in 3D Cell Culture Market

It is worth highlighting that the 3D cell culture market has witnessed several recent developments and distribution agreements anticipated to drive growth in this field.

• In September 2023, Inventia Life Science inked a distribution agreement with Biotron Healthcare to provide Inventia's RASTUM miniaturized 3D cell culturing platform into the Indian market.
• In May 2023, AMSBIO made an announcement about the launch of Matrimix (an advanced 3D cell culture substrate) with completely designed components, allowing researchers to culture a broad range of tissues.
• In April 2023, Zeiss made an investment in InSphero in order to advance the widespread adoption of 3D cell culture for the research and development of drugs.

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3D Cell Culture Market Segments

Based on the scaffold format, the 3D cell culture market is segmented into scaffold-based and scaffold-free systems.

• Based on the scaffold format, the 3D cell culture market is dominated by scaffold-based format, capturing 46% of the market share by 2035.
• Scaffold-free format will grow at a higher CAGR of 19.5% during the forecast period.

Based on products, the 3D cell culture market is segmented into hydrogel / extracellular matrix (ECM), 3D bioreactor, 3D petri dish, hanging drop player, microfluidic system, micropatterned surface, microcarrier, solid scaffold and suspension system.

• Based on the type of products, the hydrogel / extracellular matrix (ECM) will dominate the market capturing, 30% of the market share by 2035.
• Suspension culture system will grow during the forecast period at a higher CAGR of 26.5%.

Based on the application areas, the 3D cell culture market is segmented into cancer research, drug discovery and toxicology, stem cell research, tissue engineering and regenerative medicine.

• Based on the application area, the 3D cell culture market is dominated by cancer research and it is anticipated to hold 41% of the overall revenue share by 2035.
• Stem cell research will grow at a higher compounded annual growth rate (CAGR) of 17.7% during the forecast period.

Based on the purpose, the 3D cell culture market is segmented into research use and therapeutic use.

• Based on the purpose, the research use will dominate the 3D cell culture market and is poised to capture 85% of the market share by 2035.
• Therapeutic use will grow at a higher CAGR of 21.4% during the forecast period.

Based on the key geographical regions, the 3D cell culture market is segmented into North America, Europe, Asia-Pacific, Middle East and North Africa and the rest of the world.

• Based on the key geographical region, North America will dominate the 3D cell culture market, capturing 39% of the overall market share by 2035.
• In the Middle East and North Africa, the 3D cell culture market will grow at a higher CAGR of 18.3% during the forecast period.

Key Companies Profiled 

The 3D cell culture market report also includes detailed profiles of key players (listed below) that provide cell line development services solutions.

• 3D Biotek
• Advanced BioMatrix
• Alphabioregen
• CN Bio Innovations
• Corning Life Sciences
• Emulate
• InSphero
• MIMETAS
• REPROCELL
• TissUse

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Key Benefits of Buying this Report

• The report offers market leaders and newcomers valuable insights into revenue estimations for the overall market and its sub-segments.
• Stakeholders can utilize the report to enhance their understanding of the competitive landscape, allowing for improved business positioning and more effective go-to-market strategies.
• The report gives stakeholders a pulse on the 3D cell culture market, furnishing them with essential information on significant market drivers, barriers, opportunities, and challenges.

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