A novel treatment CRB091 effectively reduces cancer cell proliferation in triple-negative breast cancer (TNBC)

ZUG, Switzerland, May 4, 2023 /PRNewswire/ -- CRB091, a novel drug candidate developed by Cancer Research and Biotechnology AG (CRB), has shown significant promise in reducing cancer cell proliferation in difficult-to-treat cancers such as colorectal and triple-negative breast cancers. The preclinical studies conducted by an independent research laboratory in the UK demonstrated a significant reduction in human cancer cell proliferation in vitro, with a synergistic effect between the product's single ingredients.

TNBC is the most aggressive type of breast cancer in women with a 5-years survival rate of 66% and a very low survival rate of 12% after metastasis. Conventional cancer treatments often come with severe side effects, limiting their use and efficacy. Furthermore, targeted therapies and new immunological treatments suit only a limited patient population, while drug resistance can develop rapidly. CRB091 offers a well-tolerable and effective therapy that could address the shortfalls of existing treatments.

CRB091's active molecules have been proven safe for human use, and CRB anticipates initiating the first-in-human clinical trials in the US in 12 months. The FDA's Pre-Investigational New Drug (Pre-IND) application advice is scheduled in Q3 2023, with the IND filing in Q3 2024.

As a preclinical oncology company, CRB is focused on developing drugs that address the metabolic disease that induces carcinogenesis. By providing a particularly effective and well-tolerated therapy, CRB091 has the potential to significantly improve the treatment of triple-negative breast cancer and other difficult-to-treat cancers.

With the meaningful efficacy demonstrated on human cancer cell lines, the Switzerland-based startup is poised to take a significant step towards human use of the novel treatment.

Kari Sarvanto
Founder & CEO

Dr. Sarah Haddad
Senior Scientist

Cancer Research & Biotechnology AG contact for media and investors:
Kari Sarvanto, Mob: +41 796 162 694, E- Mail: kari@crab.ch, Mob: +41 79 6162 694, www.crab.ch

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