HistoIndex Charts New Course in Liver Disease Innovation: Announces Pivotal Changes to Scientific Advisory Board

• Company to appoint Prof. Arun J. Sanyal as the new Chairman of HistoIndex's Scientific Advisory Board, bringing unparalleled expertise to guide future innovations.
• Prof. Vlad Ratziu joins the Scientific Advisory Board to strengthen the Company's global scientific leadership in liver disease management.
• HistoIndex's AI-driven solutions qFibrosis, qSteatosis, and qBallooning can standardize assessments in MASH clinical trials, improving drug efficacy evaluations and patient screening processes.

SINGAPORE, July 1, 2024 /PRNewswire/ -- HistoIndex, a global leader in digital pathology solutions for the management of chronic liver disease, is pleased to announce changes to its Scientific Advisory Board (SAB). Established in 2017 under the leadership of the late Dr. Stephen A. Harrison, the SAB has played a crucial role in guiding HistoIndex's research and development efforts. Current members include Prof. Arun J. Sanyal, Prof. Quentin Anstee, Prof. Wei Lai, and Prof. Jacob George.

New SAB Appointments

Prof. Arun J. Sanyal, a professor of Medicine, Physiology, and Molecular Pathology at Virginia Commonwealth University (VCU) School of Medicine, has been appointed as the new Chairman of HistoIndex's SAB. Also serving as the Director of the Stravitz-Sanyal Institute for Liver Disease and Metabolic Health at VCU, Prof. Sanyal's leadership spans multiple prestigious roles as Chair of the NIH NASH Clinical Research Network, the NIMBLE consortium, and the Liver Forum. A continuous NIH grant recipient since 1995, Prof. Sanyal brings well over 500 publications in leading journals to the role, placing him in the top 0.1% of biomedical scientists globally. "I am honored to lead HistoIndex's Scientific Advisory Board," said Prof. Sanyal. "Our collective expertise will drive innovative solutions in chronic liver disease management, pushing the boundaries of scientific discovery to improve patient outcomes."

Prof. Vlad Ratziu, a professor of Hepatology at Sorbonne University and the Pitié-Salpêtrière Hospital in Paris, also joined the SAB. With over 400 publications and an H-index of 96, Prof. Ratziu is a prominent researcher in steatotic liver disease and hepatocellular carcinoma. He has played key roles in numerous MASH therapeutic trials and European research consortia, and is the incoming Editor-in-Chief of the Journal of Hepatology, a leading liver disease publication and the European Association for the Study of the Liver (EASL) flagship journal. "HistoIndex's technology has ushered in a new era in quantifying liver injury. The Company's commitment to innovation and collaboration among industry and academic leaders aligns perfectly with my scientific pursuits. I am thrilled to join the scientific board under Prof. Sanyal's leadership and contribute to innovative work benefiting MASH patients."

Remembering Dr. Stephen A. Harrison

As we embrace these new changes, we also pause to honor and remember the exceptional contributions of our late chairman, Dr. Stephen A. Harrison, a visionary leader in metabolic disease. His foresight to leverage AI for disease assessment in 2014 propelled HistoIndex's digital pathology solutions to the forefront of liver disease management. Dr. Gideon Ho, CEO of HistoIndex, reflected, "Stephen was more than our chairman; he was a true pioneer and mentor whose persistence and guidance brought our technology to maturation for enhanced patient care. His legacy will continue to inspire our work as we expand the applications of our platform technology to other diseases."

Innovative AI Tools

HistoIndex's pioneering AI-based image quantitative tools, qFibrosis and qSteatosis, have been incorporated in over 25 MASH clinical trials and demonstrated greater sensitivity in drug efficacy evaluations and patient stratification. Building on the same AI foundations, the Company developed qBallooning, which improved concordance among expert pathologists in ballooned hepatocyte evaluations. "Developing qBallooning is a significant step in standardizing and improving the evaluation of liver biopsies in MASH clinical research and practice," said Dr. Dean Tai, Chief Scientific Officer. "With these advancements and our strengthened SAB, HistoIndex is poised to accelerate liver disease drug development and diagnosis breakthroughs."

About HistoIndex

Founded in 2010, HistoIndex is a pioneer in stain-free, fully automated imaging solutions for visualizing and quantifying fibrosis in tissue biopsies. By combining cutting-edge biophotonic technology with AI-based analysis, HistoIndex provides innovative tools that transform research, expedite pharmaceutical drug development, and set new medical standards.

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