Influenza Pipeline Looks Promising as 100+ Companies Working in the Domain, Assesses DelveInsight

The rapid spread of influenza virus worldwide is driving the demand for the development of efficient influenza vaccine. Increasing clinical trials for new product development by market players is going to propel the global influenza vaccine market. Major players include: Moderna, SAB Biotherapeutics, ENA Respiratory Pty Ltd, Codagenix, AlloVir, Osivax, CureVac AG, GlaxoSmithKline, Cocrystal Pharma Inc., Viriom and several others.

LAS VEGAS, Aug. 31, 2022 /PRNewswire/ -- DelveInsight's 'Influenza Pipeline Insight 2022' report provides comprehensive global coverage of available, marketed, and pipeline influenza therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the influenza pipeline domain.

Key Takeaways from the Influenza Pipeline Report

• DelveInsight's influenza pipeline report depicts a robust space with 100+ active players working to develop 110+ pipeline therapies for influenza treatment. 
• Leading influenza companies such as Moderna, SAB Biotherapeutics, ENA Respiratory Pty Ltd, Codagenix, AlloVir, Osivax, CureVac AG, GlaxoSmithKline, Cocrystal Pharma Inc, Viriom, Emergent BioSolutions, Pfizer, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Guangdong Raynovent Biotech Co., Ltd, FluGen Inc, BlueWillow Biologics, AVM Biotechnology LLC, Ansun Biopharma, Inc., Guangzhou Henovcom Bioscience, Sunshine Lake Pharma Co., Ltd., Emergex Vaccines, Vir Biotechnology, CSL Limited, Novavax, Mitsubishi Chemical Group Corporation, Poolbeg Pharma, MYMETICS, CELLTRION INC., Avalia Immunotherapies, Meiji Holdings Co., Ltd., Clover Biopharmaceuticals, Airway Therapeutics, Inc., PrEP Biopharm, Cidara Therapeutics, Inc., Medicago, Sanofi, Translate Bio, Arcturus Therapeutics, Inc., BiondVax Pharmaceuticals, Adagio Therapeutics, Virpax Pharmaceuticals, Blue Water Vaccines, SINOVAC, PDS Biotechnology, Pneumagen, Abivax, Seqirus, ExpreS2ion Biotechnologies, Vivaldi Biosciences, Ethris, GC Biopharma, AIM ImmunoTech, Eyam Vaccines And Immunotherapeutics, SyneuRx, and others are evaluating novel antiviral influenza drugs candidate to improve the treatment landscape.
• Key influenza pipeline therapies in various stages of development include mRNA-1010, SAB-176, INNA-051, CODA-VAX H1N1, DAS181, ALVR106, OVX836, VIR-2482, POLB 001, CD388, CT-P27, KD-404, AVA2300, CVSQIV, GSK3206641A, UniFlu, CC-42344, AV5080, mRNA-1073, UFluA, PF-07852352, GP681, ZSP1273, Sing2016, BW-1014, AVM0703, DAS181, HNC042, HEC116094, Adjuvanted Cell Culture Influenza Vaccine (aQIVc), NanoFlu, MT-8972, MT-7529, MT-2654, PrEP-001,GSK4382276A, mRNA Influenza Vaccine, LUNAR-FLU, M–001, Adintrevimab, PDS0202, Neumifil, Influenza vaccine, ETH47, GC3114A,  and others.
• Add recent developments
• In July 2022, Emergex Vaccines Holding Limited through the development of fully synthetic CD8+ T cell Adaptive Vaccines, announced the manufacture of its universal/pandemic influenza vaccine, ready for Phase I clinical trials.
• CureVac has dosed the first participant in a Phase I study of the modified influenza vaccine candidate FLU SV mRNA, developed in collaboration with GSK. The study follows the start of a Phase I study in February 2022 to evaluate an unmodified, multivalent influenza vaccine candidate, CVSQIV, at clinical sites in Panama. Data from both studies are expected to be reported as a combined data set.
• In June 2022, Moderna, Inc. announced the first participants have been dosed in a Phase III study of the Company's seasonal influenza vaccine candidate (mRNA-1010). The trial is expected to enroll approximately 6,000 adults in Southern Hemisphere countries. This Phase III randomized, observer-blind study is designed to evaluate the safety and immunological non-inferiority of mRNA-1010 to a licensed seasonal influenza vaccine in adults 18 years and older.
• In April 2022, Novavax, Inc. announced initial results from the Phase I/II clinical trial of its COVID-Influenza Combination Vaccine (CIC). The CIC combines Novavax' COVID-19 vaccine, NVX-CoV2373, and its quadrivalent influenza vaccine candidate. The CIC trial demonstrated that formulating the combination vaccine is feasible, well-tolerated and immunogenic.
• In April 2022, Osivax, announced the Phase IIa results for its broad-spectrum influenza vaccine candidate, OVX836, have been published under the title "Randomized, Double-Blind, Reference-Controlled, Phase IIa Study Evaluating the Immunogenicity and Safety of OVX836, A Nucleoprotein-Based Influenza Vaccine" in the journal Frontiers in Immunology. Developed using Osivax' proprietary self-assembling nanoparticle technology, OVX836 targets an internal nucleoprotein (NP), a highly conserved antigen that is less susceptible to the constant mutations of surface antigens of the influenza virus. 
• BioNTech is collaborating with Pfizer to develop an influenza vaccine based on BioNTech's suite of mRNA platforms. In July 2022, data were reported from the Phase II expansion study of BNT161 in subjects 65 years of age and older showing first evidence of substantial induction of strain specific CD4+ and CD8+ responses. The GMFR was higher compared to the control quadrivalent influenza vaccine for both CD4+ and CD8+ strain specific T cell responses. Based on these encouraging T cell responses and observed seroconversion, a Phase III study of the quadrivalent modified mRNA influenza vaccine is planned to initiate in the second half of 2022.
• In May 2022, Blue Water Vaccines announced a collaboration with the multidisciplinary Center for R&D in Immunobiologics, an initiative of Instituto Butantan , for the development of BWV's universal influenza candidate, BWV-101, in Brazil. Butantan is the largest flu vaccine manufacturer in the Southern Hemisphere, with 100% of influenza vaccine doses used by the Brazilian Ministry of Health manufactured at Butantan.

Request a sample and discover the recent advances in influenza treatment @ Influenza Pipeline Report

The influenza pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage influenza drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the influenza pipeline landscape. 

Influenza Overview

Influenza, one of the most common infectious diseases, is a highly contagious airborne disease that appears as an acute febrile sickness with varying degrees of systemic symptoms ranging from mild fatigue to respiratory failure and death. Influenza causes enormous workday loss, human suffering, and fatality. Viral culture from nasopharyngeal or throat samples is the gold standard for influenza diagnosis.

At first, the influenza symptoms may appear to be a normal cold, with a runny nose, sneezing, and sore throat. However, colds normally develop gradually, whereas the flu frequently appears abruptly. Antiviral drugs are the sole influenza treatment option.

Find out more about influenza tests @ Influenza Medication 

A snapshot of the Influenza Pipeline Drugs mentioned in the report:

Learn more about the novel and emerging influenza pipeline therapies @ Influenza Clinical Trials

Influenza Therapeutics Assessment

The influenza pipeline report proffers an integral view of the Influenza emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.

Scope of the Influenza Pipeline Report 

• Coverage: Global 
• Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
• Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• Therapeutics Assessment By Route of Administration: Inhalation, Intranasal, Parenteral, Oral, Intravenous, Subcutaneous, Intramuscular
• Therapeutics Assessment By Molecule Type: Antibody, Antisense oligonucleotides, Immunotherapy, Monoclonal antibody, Peptides, Protein, Recombinant protein, Small molecule, Stem cell, Vaccine
• Therapeutics Assessment By Mechanism of Action: Immunostimulants, Toll like receptor 2 agonists, Toll like receptor 6 agonists, Immunologic cytotoxicity, T lymphocyte replacements, Influenza virus PB2 protein inhibitors, Endonuclease inhibitor, DNA-directed RNA polymerase inhibitor, Neuraminidase inhibitor, RNA synthesis inhibitor.
• Key Influenza Companies: Moderna, SAB Biotherapeutics, ENA Respiratory Pty Ltd, Codagenix, AlloVir, Osivax, CureVac AG, GlaxoSmithKline, Cocrystal Pharma Inc, Viriom, Emergent BioSolutions, Pfizer, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Guangdong Raynovent Biotech Co., Ltd, FluGen Inc, BlueWillow Biologics, AVM Biotechnology LLC, Ansun Biopharma, Inc., Guangzhou Henovcom Bioscience, Sunshine Lake Pharma Co., Ltd., Emergex Vaccines, Vir Biotechnology, CSL Limited, Novavax, Mitsubishi Chemical Group Corporation, Poolbeg Pharma, MYMETICS, CELLTRION INC., Avalia Immunotherapies, Meiji Holdings Co., Ltd., Clover Biopharmaceuticals, Airway Therapeutics, Inc., PrEP Biopharm, Cidara Therapeutics, Inc., Medicago, Sanofi, Translate Bio, Arcturus Therapeutics, Inc., BiondVax Pharmaceuticals, Adagio Therapeutics, Virpax Pharmaceuticals, Blue Water Vaccines, SINOVAC, PDS Biotechnology, Pneumagen, Abivax, Seqirus, ExpreS2ion Biotechnologies, Vivaldi Biosciences, Ethris, GC Biopharma, AIM ImmunoTech, Eyam Vaccines And Immunotherapeutics, SyneuRx, and others
• Key Influenza Pipeline Therapies: mRNA-1010, SAB-176, INNA-051, CODA-VAX H1N1, DAS181, ALVR106, OVX836, VIR-2482, POLB 001, CD388, CT-P27, KD-404, AVA2300, CVSQIV, GSK3206641A, UniFlu, CC-42344, AV5080, mRNA-1073, UFluA, PF-07852352, GP681, ZSP1273, Sing2016, BW-1014, AVM0703, DAS181, HNC042, HEC116094, Adjuvanted Cell Culture Influenza Vaccine (aQIVc), NanoFlu, MT-8972, MT-7529, MT-2654, PrEP-001,GSK4382276A, mRNA Influenza Vaccine, LUNAR-FLU, M–001, Adintrevimab, PDS0202, Neumifil, Influenza vaccine, ETH47, GC3114A, and others.

Dive deep into rich insights for drugs for influenza treatment, visit @ Influenza Vaccine

Table of Contents

For further information on the influenza pipeline therapeutics, reach out @ Antiviral Influenza Drugs

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